Hope of Cure for Fatal Brain Diseases
Author: Subhash
SCIENTISTS HAVE developed a revolutionary new treatment for neurological diseases that uses an injection to tweak the way genes work in the brain.
The research raises hopes for a new era of effective treatments for some of the most debilitating - and so far incurable - brain conditions, including cancer and Alzheimer's disease.
Tests of the therapy at Harvard Medical School in Boston found that a simple injection was able to cure mice of a potentially fatal brain disease. The re- searchers behind the breakthrough are planning further tests and expect to conduct human trials within five years.
The team used a powerfill new technique called RNA interference to silence faulty genes or viruses that cause brain diseases. The principle of gene silencing is simple: scientists build tiny strands of the genetic material called RNA which, when injected into cells, latch on to problematic genes and smother them, effectively shutting them down.
Until now, attempts to use gene silencing to treat brain diseases have been severely hampered for two reasons. First, many drugs injected into the body are barred from getting into the brain by a membrane that protects it from viruses and microbes in the bloodstream.
Because of this, most gene-silencing treatments require nijections directly into the brain - a second serious drawback because it involves a dangerous surgical procedure and only delivers the treatment to the cells at the end of the needle.
The Harvard team, led by Man- junath Swamy, found a simple way around these problems. They made strands of therapeutic RNA in the lab and mixed them with a tiny part of the rabies virus which helps it get into the brain and infect cells. The key-like fragment is harmless on its own.
Researchers squirted some of the mixture on to a dish of nerve cells and found that the strands of RNA they had created were smuggled inside the cells, where they shut down certain genes. The team tested the therapy on mice that had been infected with a fatal brain disease, viral encephalitis. The scientists found that regular injections of RNA mixed with the rabies virus fragment shut down genes in around half of the cells in the animals' brains and stopped the disease from spreading. Of the mice that received injections, 80 per cent were cured, while those that were untreated died, the team reported in Nature.
"We expect this work to move quite fast now, because there is so much interest in this kind of treatment. Potentially, it could be used for a wide variety of neurodegenerative diseases, but also for controlling cancers that spread to the brain," said Professor Swamy.
Article Source: http://www.articlesbase.com/medicine-articles/hope-of-cure-for-fatal-brain-diseases-167586.html
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[TEMPLATE]cannibis[/TEMPLATE]
Can you mix hydrocode and diazapam?
I have a severe toothache and i have pains pills for other problems i have had.
Ive take 1000Mg of hydrocode and it still isn’t helping any. I tried using home remedies such as oral gel(which seemed to work for about an hour and then stopped working) cloves, and salt water.
My last resort is either taking another pain pill of hydrocode or mixing one of these two:
Hydrocodone with Diazapam(valium)
OR
Hydrocodone with Tramadol
OMG 1000 mg of Hydrocodone???? Since Hydrocodone must be mixed with a second medication like tylenol, I would be more worried about your liver lasting another 24 hours. I hope you mean 1000mg over a month, not per day, because even if you were taking 10/325 that would be 32 grams of tylenol which is flat out LETHAL. The liver is NOT a forgiving organ when it comes to tylenol overdose which is supposed to be no more than 4000mg per day. Something doesn’t sound right. Are you sure you didn’t mean codeine? If not and you are taking 100 pills a day, your liver will explode!!!!!!!!!!!!
To answer your other question, if you read about many of the celebrity OD’s you will usually see it included benzo’s like Valium or Xanax. Both meds disrupt the brains ability to monitor Co2 levels and this can lead to pulmonary edema and respiratory depression when you simply stop breathing, while downing in your own lung fluids.
I can’t believe that you could be taking 1000mg of Hydrocone since it is NOT sold without a riding medicine like any number of NSAID’s like tylenol. If you have a disease which requires that kind of level, and you are seeing a doctor, you should be on Oxycodone and/or duragesic fentanyl patces. But these meds are usually reserved for deathbed conditions or very serious confitions.
So something doesn’t add up unless you meant codeine and not hydrocodone, or your 1000mg is for a month long.
either way, unless under VERY careful doctor’s orders, mixing benzo’s and opioids (natual analagesicd, where opiatesare synthetic) from t and/or opiates, is a dangerous combination due to synergy and potehe mntiation.
Tramadol is in the same boat, except it is only 1/1000 as morphine. tramadol is a risky med all on its own due to being tied to seizures, and rarely a condition called seratonin syndrome.
Finally, if you do take very high doses of Hydrocone//tylenol you should be taking a medication called NAC. Otherwise you might be facing a VERY painful death with liver failure. But 32 grams of tylenol taken in one day you should go to the er immidiately!!!
HELP im going more mad each day!!?
Well i could be here all day..
I got sexually abused when i was younger that has left me very confused cause im adopted and makes me wonder why they chose to adopt me?, i started smokin cannabis + smoking + drinking when i was 10/11 stopped smoking cannabis for like a year then started again heavily then got involved with loads of drugs like thousands of E’s, amphetamines, valium and some other stuff. Im also gay but at that time was trying to cover it up making me extremely paranoid, on top of the drugs so i ended up making up things in my head, delusions, I had a few REALLLY bad hallucinations which i’ve never felt the same since that made me worse so i stopped drugs and done detox for a month. I’ve been off everything apart from the occasional drink for about 7 months and stopped smoking cannabis for about a year now cause that was the main paranoia/anxiety/delusions ect. I came out the closet and split up with my 2 and half year long relationship with a female for like the 3rd time but serious this time but got back with her a few times for sex and she got pregnant but she was also sleeping with somebody else so i dont know who the father is. I had to leave my mums house cause she didnt understand my problems cause even after i stopped taking drugs im still just as paranoid ect. And im living on my ex-girlfriends couch and helping looking after her (maybe mine)s baby. We havent had a DNA test yet cause i dont have the money. I have serious depression + paranoia issues, i gradually left high school cause i couldnt handle it i cant mix with people anymore cause im preoccupied with things in my head when im talking to them. I tried college but it was worse cause i didnt know anybody and i got so paranoid i had to leave the class and never went back!! i just want my personality back i used to be happy bubbly and funny now im just depressing, sometimes stuttery and have extreme mood swings. Im seeing a phsyciatrist ( cant spell it) but she doesnt understand and is just brushing things over. I know theres something wrong cause im under delusions people are doing things on purpose and always look for hidden meanings in things..oh yeah i told my mum that my dad abused me and she didnt beleive me i told my sister and she said “why didnt he do that to me”. I DONT F**KING know!! maybe cause he is a freak?? Theres loads more but HELPPPPP
I tried to commit suicide a while ago by taking all the drugs in my house like 2 packets paracetamol, 2 bxes cocodamol tramadol anyway the list could go on. Thats how i ended up with the psyciatrist.
I deal with life now by sitting playing games all day to keep my mind of everything and my cat helps me a lot lol. My ex is great too but also adds extra stress coz we argue a lot coz shes upset im gay and i feel bad for that and i feel like ive used her or im using her coz im on her couch but im trying to find a house and need confidence to get a job thats the main thing. My “dad” i want to confront him again and make him admit it so i dont look like a freak my physciatrist told me its not my fault but ive grown up confused that it was my fault coz i was so young at the time and didnt understand
P.s i just made this question thingy but missed out a few important things
if u just read it thanks for ur answers they made me feel a bit better.
Wow.
You should just calm down and think for a secound.
(A) it’s not your fault that your dad treats you like this. He obviously has problems too. Why don’t you first find a hobby? Perhaps you like sport, or art, or something like your games that take your mind of everything a little and makes you happier. Also try and have a role model.
(B) Drugs really dont help. If your addicted, admit and go to a gp so they can help you or something. Drugs waste money and, honestly, your life. You should go back to the funny, bubbly guy. Drugs don’t help.
(C) Why do you feel gay? Why do you have an unnatural feeling towards men? Is it because you were abused when you were younger? If you don’t mind me taking a reference from a book i read, “the woman was made so that the man may seek comfort in her”. Women, naturally, have insinctive loving, caring, symphathetic feelings and also are more social in general than men.
i know this may sound seriously bad to you, but why don’t you think about religion? You may not think so, but religion has every answer in the world. You may think islam has terrorists and forced marriages, but if you read up you’ll find out its all lies what the media shows. I’ve read a lot about Islam because i’m so so curious about what they do and i have loads of answers to problems now and im alot happier.
For instance; Islam actually says that you shouldn’t have girlfriends because it will give you loads of problems like not knowing who the kid is and stuff. You should marry to find out if the girl takes you seriously and then have a kid. Talk about this to your girlfriend. Tell her everything you feel. If she’s good, she will try and sort out the situation.
(D) Try and find a career. Now you’ve found you’re hobby, do you want to make it a career? Take Ronny o’sullivan. His dad went to prison, he’s depressed and stuff, but he does what he love and has money at least. This will put you in a good position. With a job in one hand, and money in the other, and hopefully a good, engaged wife in the other, you’ll brighten up.
(E) Try and have a family discussion. Now i know your upser because of your dad, and you may feel like commiting suicide, but you have a life, a future. Who knows what you could do if you didnt kill yourself? You could be succesful.
This may take ages, but you’ll be happy soon. Whatever you do, dont take drugs or try to kill yourself.